
The seeds of the plant contain between six and 20 percent 5-Hydroxytryptophan is an important building block for the human body to form serotonin, a neurotransmitter. In one “randomized, double-blind, placebo-controlled trial” in 2010 Griffonia simplicifolia extract, was administered via oral spray to twenty overweight females resulting in increased satiety. Griffonia simplicifolia also has a legume lectin called GS Isolectin B4, which binds to alpha-D-galactosyl residues of polysaccharides and glycoproteins. This supplement is often given by spider silk farmers to increase production of stronger silk.
Introduction
Medicinal plants play a crucial role in traditional folk practices, providing effective treatments for a wide range of diseases. Their bioactive molecules can operate both individually or in combination with other substances, demonstrating a peculiar therapeutic potential . Moreover, in comparison to synthetic drugs, natural phytopharmaceuticals have greater acceptance from consumers, improved bioavailability, better safety profiles, and lower toxicity.
G. simplicifolia also contains other notable bioactive compounds, such as tannins, flavonols, and carbolide alkaloids [8], which exert a variety of biological actions, including antioxidant, anti-inflammatory, antibacterial, and anticancer activity. Accordingly, the use of G. simplicifolia extracts has been investigated for its potential applications in the treatment of migraine, irritable bowel syndrome, fibromyalgia, binge eating, and chronic headache
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Origin and Distribution of Griffonia simplicifolia
- Scientific Name: Griffonia simplicifolia
- Family: Fabaceae (legume family)
- Common Names: Griffonia, African legume shrub
- Native to: West and Central Africa (especially Ghana, Côte d’Ivoire, Togo)
Botanical Description of Griffonia simplicifolia
- Type: Climbing shrub or small tree
- Height: Grows up to 3 meters
- Leaves: Broad, green, and oval-shaped
- Flowers: Small greenish flowers
- Fruits: Seed pods with black seeds
Medicinal Components of Griffonia simplicifolia
- Seeds: Contain high levels of 5-Hydroxytryptophan (5-HTP)
- 5-HTP is a natural substance that the body uses to make serotonin, a brain chemical that helps regulate mood, sleep, and appetite.
Health Benefits and Traditional Uses
- Mood Support: Used as a natural supplement to increase serotonin and improve mood; may help with symptoms of depression and anxiety.
- Appetite Control: One study showed that it helped reduce hunger and improve feelings of fullness in overweight individuals.
- Sleep Aid: May help support better sleep by increasing serotonin, which is needed to make melatonin (the sleep hormone).
- Migraine Relief: Sometimes used to help prevent migraines.
- Fibromyalgia and PMS: Used in some cases to help with pain and mood swings.
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Other Uses
- Contains a plant protein called GS Isolectin B4, used in scientific research.
- Sometimes given to spider silk-producing spiders to strengthen silk threads.
⚠️ Caution
- Should not be taken with antidepressants or other medications that affect serotonin.
- Always consult a healthcare provider before using it as a supplement.